TokuTBNK: Global cytometry for clinical trials made simple

Eliminate the 72-hour cytometry deadline with preserved samples that capture immune biology at blood draw

Clinical trials using cytometry to track pharmaco-kinetics and -dynamics of immune responses face a major challenge: samples must be processed by cytometry within 72 hours of collection. This requirement limits where trials can run cytometry and often compromises data quality as samples degrade during transport to specialized cytometry labs.

Teams consistently face key challenges:

• Finding cytometry near clinical trial sites - Only trial sites near cytometry facilities can profile samples by cytometry, restricting global trial reach.‍
• Sample degrade even if processed within 72 hours - Immune cells change (and often die) during the 24-72 hour transport window, negatively affecting data, results, and insights.‍
• Complex logistics - Coordinating rapid sample processing across multiple sites creates operational headaches (this is a big one).‍
• Inconsistent quality - Different labs, instruments, and processing plus processing delays lead to variable results. You start studying technical variation opposed to true MOA and patient biology.

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TokuTBNK solves these problems enabling cytometry profiling on blood preserved with Teiko's TokuKit. The 3-step preservation process profiles immune cells exactly as they are at blood draw, eliminating time pressure and transport concerns. The TBNK assay is CLIA-validated, with single-digit LOQs, performed at Teiko's CLIA compliant laboratory ensuring accurate enumerations of immune cells in absolute counts and as a relative frequency.

Simple Sample Collection that Preserves Immune Cells

TokuKit makes sample collection straightforward at any clinical site. The 3-step preservation process fixes whole blood samples within hours of collection, removing the 72-hour processing deadline and preserving immune cells exactly as they were at the time of draw.

Drop-in Channels to Track Engineered Cells and Target Effects

Choose the cytometry panel that fits your trial:

Standard Panel: Six core markers (CD3, CD4, CD8, CD19, CD56, CD16) provide complete immune profiling across all major cell types.

Custom Add-ons: 1-2 additional markers tailored to your specific needs:

• Track therapeutic cells: Monitor CAR-T or other engineered cell therapies over time
• Measure target effects: Track how treatments affect specific immune populations

Reliable, Reproducible Results at Single-Digit LOQs

High sensitivity: Detect as few as 0.5-5 cells/μL for rare but important cell populations

Consistent quality: Less than 25% variation between samples ensures reliable data

Fast turnaround: Results available within 3 days of sample receipt

Complete data: Both cell counts and percentages for comprehensive analysis

Your results are delivered through a secure, interactive dashboard where you can explore data immediately. No waiting for static reports – everything you need is available online as soon as analysis is complete.

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Clinical-Grade Quality

TokuTBNK operates in a CLIA-certified lab using advanced spectral flow cytometry. Our validation meets clinical trial regulatory requirements, giving you confidence in data quality and regulatory submissions.

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Why TokuTBNK Works Better

Global reach: Run trials anywhere without worrying about local cytometry facilities

Better data: Fixed samples preserve biology at collection, eliminating transport artifacts

Faster results: 3-day turnaround enables quick clinical decisions

Regulatory ready: CLIA validation and clinical documentation included

Learn more about TokuTBNK at www.teiko.bio

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